ABSTRACT
BACKGROUND/AIMS: Postprandial symptoms of fullness and abdominal discomfort are common after fatty meals. Gastric lipases hydrolyze 10% to 20% of dietary triglycerides during the stomach trituration period of digestion. The aim of this study was to evaluate the effects of acid-resistant lipase on upper gastrointestinal symptoms, including fullness and bloating, as well as on gastric myoelectrical activity after healthy subjects ingested a high-fat, liquid meal. METHODS: This study utilized a double-blind, placebo-controlled, crossover design with 16 healthy volunteers who ingested either a capsule containing 280 mg of acid-resistant lipase or a placebo immediately before a fatty meal (355 calories, 55% fat). Participants rated their stomach fullness, bloating, and nausea before and at timed intervals for 60 minutes after the meal. Electrogastrograms were obtained to assess the gastric myoelectrical activity. RESULTS: Stomach fullness, bloating, and nausea increased significantly 10 minutes after ingestion of the fatty meal (p<0.01), whereas normal gastric myoelectrical activity decreased and tachygastria increased (p<0.05). With lipase, reports of stomach fullness were significantly lower compared with placebo (p<0.05), but no effect on gastric myoelectrical activity or other upper gastrointestinal symptoms was observed. CONCLUSIONS: The high-fat meal induced transient fullness, bloating, nausea, and tachygastria in healthy individuals, consistent with post-prandial distress syndrome. Acid-resistant lipase supplementation significantly decreased stomach fullness.
Subject(s)
Adult , Female , Humans , Male , Middle Aged , Young Adult , Abdominal Pain/etiology , Cross-Over Studies , Diet, High-Fat/adverse effects , Dietary Supplements , Double-Blind Method , Dyspepsia/etiology , Gastrointestinal Motility/drug effects , Healthy Volunteers , Lipase/administration & dosage , Meals , Myoelectric Complex, Migrating , Nausea/etiology , Postprandial Period , Stomach/drug effectsABSTRACT
No abstract available.
Subject(s)
Female , Humans , Male , Diet, High-Fat/adverse effects , Dietary Supplements , Dyspepsia/prevention & control , Lipase/administration & dosage , Stomach/drug effectsABSTRACT
Disutem-se, neste trabalho, as características e a tecnologia de fabricaçäo do queijo provolone. A utilizaçäo do ênzimo lipase é enfatizada